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KMID : 0854720090290040269
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Korean Journal of Asthma, Allergy and Clinical Immunology
2009 Volume.29 No. 4 p.269 ~ p.276
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Effect of DHEA Ingestion on Atopic Dermatitis-like Lesion in BALB/c Mice Sensitized by Ovalbumin
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Won June-Ho
Kim Seong-Jin
Choi In-Seon
Won Young-Ho
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Abstract
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Background: Atopic dermatitis (AD) is a chronic cutaneous inflammatory disorder. Dehydroepiandrosterone (DHEA) is a sex hormone normally secreted from the adrenal gland and is used to treat various disorders. It decreases in the serum of AD patients and is known to attenuate dust mite- induced airway allergic responses associated with reduced Th2 cytokine.
Objective: The authors attempted investigate the effect of DHEA on AD-like skin lesions by reviewing the cytokine profile and specific IgE production in BALB/c mice sensitized with ovalbumin (OVA).
Method: Mice were sensitized by intraperitoneal injection of OVA, followed by epicutaneous sensitization for 5 weeks. DHEA was given by the oral route. After all mice were sacrificed at the end of the experiment, skin, spleen tissue and blood were harvested.
Result: Gross and histological examinations of skin lesions showed inflammation. The severity was mild or absent in DHEA-ingested mice and the number of inflammatory cells was significantly reduced. The IL-5 levels in the cultured splenocytes significantly decreased in the sensitized mice than in the control group. The IFN-γ/IL-5 ratio significantly increased in the sensitized mice.
Conclusion: DHEA ingestion may suppress OVA-induced AD-like skin lesions and prevents the cytokine production of Th2 cells.
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KEYWORD
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Atopic dermatitis, Dehydroepiandrosterone, Mice, Ovalbumin
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